News

A Swiss Army Knife for Genomic Data

04-05-21

A good way to find out what a cell is doing—whether it is growing out of control as in cancers, or is under the control of an invading virus, or is simply going about the routine business of a healthy cell—is to look at its gene expression. Lior Pachter, Bren Professor of Computational Biology and Computing and Mathematical Sciences, has developed a complex software tool that enables the processing of large sets of genomic data in about 30 minutes, using the computing power of an average laptop. Like a Swiss Army knife, the tool can be used in myriad ways for different biological needs, and will help ensure the reproducibility of scientific studies. "The interdisciplinarity of our team was crucial to conceiving of and executing this project," says Pachter. "There are people in the lab who are computer scientists, biologists, engineers. Sina Booeshaghi is in the mechanical engineering department and brings the perspective of his design background and engineering." [Caltech story]

Tags: research highlights MCE CMS Lior Pachter Sina Booeshaghi

Astronomers Image Magnetic Fields at the Edge of M87's Black Hole

03-24-21

The Event Horizon Telescope (EHT) collaboration, which produced the first-ever image of a black hole, revealed a new view of the massive object at the center of the M87 galaxy: a picture of its polarized light. This is the first time astronomers have been able to measure polarization, a signature of magnetic fields, this close to the edge of a black hole. "We are now able to see a different dimension of the light circling the M87 black hole," says Katie Bouman, Assistant Professor of Computing and Mathematical Sciences, Electrical Engineering and Astronomy, Rosenberg Scholar, and co-coordinator of the EHT Imaging Working Group. "The image we reconstructed earlier showed us how bright the light was around the black hole shadow. This image is telling us about the direction of that light." [Caltech story]

Tags: EE research highlights CMS Katie Bouman

Professor Bouman Featured in Inverse Magazine

03-10-21

Katie Bouman, Assistant Professor of Computing and Mathematical Sciences, Electrical Engineering and Astronomy; Rosenberg Scholar, was featured in Inverse Magazine as one of the astronomers who captured the first image of a black hole. In 2019, Bouman and a group of more than 200 astronomers from all over the world managed the inconceivable: They captured the first image of a black hole, rendering the invisible visible. "Ideally, to see a black hole, we would need a telescope the size of the entire Earth," says Bouman. "We had to come up with a computational telescope that size." [Inverse article]

Tags: EE research highlights CMS Katie Bouman

Paul Rothemund Places Molecule-Scale Devices in Precise Orientation

02-22-21

Paul Rothemund, Research Professor of Bioengineering, Computing and Mathematical Sciences, and Computation and Neural Systems, has developed a technique that allows him to precisely place microscopic devices formed from folded DNA molecules in not only a specific location but also in a specific orientation. This method for precisely placing and orienting DNA-based molecular devices may make it possible to use these molecular devices to power new kinds of chips that integrate molecular biosensors with optics and electronics for applications such as DNA sequencing or measuring the concentrations of thousands of proteins at once. [Caltech story]

Tags: research highlights CMS Paul Rothemund KNI CNS

Metals that Work Like Magic

02-16-21

Metals that Work Like Magic, a podcast from the Wall Street Journal, features Jamil Tahir-Kheli, research staff member working with Carver Mead, Gordon and Betty Moore Professor of Engineering and Applied Science, Emeritus. The podcast focuses on the history of superconductivity research over the past forty years and potential applications.

Tags: EE research highlights CMS Carver Mead CNS Jamil Tahir-Kheli

AI-Driven COVID-19 Model Outperforms Competitors

11-30-20

While existing models to predict the spread of a disease already exist, few, if any, incorporate artificial intelligence (AI). Yaser Abu-Mostafa, Professor of Electrical Engineering and Computer Science, is using a new model for predicting COVID-19's impact using AI and it dramatically outperforms other models, so much so that it has attracted the interest of public health officials across the country. "AI is a powerful tool, so it only makes sense to apply it to one of the most urgent problems the world faces," says Yaser Abu-Mostafa. [Caltech story]

Tags: EE research highlights CMS Yaser Abu-Mostafa CNS

Robotics Engineers Take on COVID-19

11-18-20

Methods that were originally created to help robots to walk and autonomous cars to drive safely can also help epidemiologists predict the spread of the COVID-19 pandemic. Aaron Ames, Bren Professor of Mechanical and Civil Engineering and Control and Dynamical Systems, and colleagues took these tools and applied them to the development of an epidemiological methodology that accounts for human interventions (like mask mandates and stay-at-home orders). By utilizing the U.S. COVID-19 data from March through May, they were able to predict the infection wave during the summer to high accuracy. "This is the greatest health challenge to face our society in a generation at least. We all need to pitch in and help in any way we can," Ames says. [Caltech story]

Tags: research highlights MCE CMS IST Aaron Ames CDS Andrew Singletary

Machine Learning Speeds Up Quantum Chemistry Calculations

10-07-20

A new quantum chemistry tool, called OrbNet, uses machine learning, quantum-chemistry calculations that can be performed 1,000 times faster than previously possible, allowing accurate quantum chemistry research to be performed faster than ever before. OrbNet was developed through a partnership between Tom Miller, Professor of Chemistry, and Anima Anandkumar, Bren Professor of Computing and Mathematical Sciences. [Caltech story]

Tags: research highlights CMS IST CNS Animashree Anandkumar

A Molecular Approach to Quantum Computing

09-03-20

The technology behind the quantum computers of the future is fast developing, with several different approaches in progress. Many of the strategies, or "blueprints," for quantum computers rely on atoms or artificial atom-like electrical circuits. In a new theoretical study in the journal Physical Review X, Caltech demonstrates the benefits of a lesser-studied approach that relies not on atoms but molecules. One concept behind the new research comes from work performed nearly 20 years ago by John Preskill, Richard P. Feynman Professor of Theoretical Physics; Allen V. C. Davis and Lenabelle Davis Leadership Chair, Institute for Quantum Science and Technology, Alexei Kitaev, Ronald and Maxine Linde Professor of Theoretical Physics and Mathematics, and their colleague Daniel Gottesman. [Caltech story]

Tags: research highlights CMS Alexei Kitaev John Preskill

Advancing Future Quantum Science Efforts

08-27-20

Five new Department of Energy centers will apply quantum information science to emerging technologies. The centers will develop cutting-edge quantum technologies for use in a wide range of possible applications including scientific computing; fundamental physics and chemistry research; and the design of solar cells and of new materials and pharmaceuticals. Caltech faculty will participate in four of the new science centers: the Quantum Systems Accelerator, led by the Lawrence Berkeley National Laboratory, also known as Berkeley Lab; the Quantum Science Center, led by Oak Ridge National Laboratory; Q-NEXT, led by Argonne National Laboratory; and the Co-design Center for Quantum Advantage, led by Brookhaven National Laboratory. [Caltech story]

Tags: APhMS EE research highlights MedE CMS Oskar Painter KNI Andrei Faraon